Cellular Differentiation and the Aging Process in Cartilaginous Tissues

نویسندگان

  • Herbert J. Shulman
  • Karl Meyer
چکیده

Primary cell cultures of differentiated chondrocytes were shown to produce chondroitin-4-sulfate as the predominant mucopolysaccharide, with suggestive evidence for the synthesis of keratan sulfate and possibly chondroitin-6-sulfate. Chicken embryonic cartilage was shown to be composed mainly of chondroitin-4-sulfate, with a small amount of chondroitin-6-sulfate, but essentially no keratan sulfate. These findings were compared to the data of others, and a hypothesis explaining the aging process in cartilage in terms of cellular differentiation was presented.

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عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 128  شماره 

صفحات  -

تاریخ انتشار 1968